GLIMEPIRIDE 2mg, METFORMIN 500 mg SR Tablet

Description

Glimepiride and Metformin tablets are supplied under the brand name INSIUP DUO-2 (SR). These combination tablets are an oral antidiabetic medication used to manage type 2 diabetes mellitus when diet, exercise, and monotherapy do not provide adequate glycemic control. Glimepiride is a sulfonylurea that stimulates insulin secretion from pancreatic beta cells, while Metformin is a biguanide that reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues. This dual-action therapy helps lower both fasting and postprandial blood glucose levels. The combination is particularly beneficial for patients requiring better glycemic control than either drug alone can provide. 

These tablets are manufactured by Mestra Pharma, an ISO- and GMP-certified company, which produces the ultimate formulations of Glimepiride and Metformin tablets and supplies them worldwide. Mestra Pharma also offers great career opportunities for various young entrepreneurs who want to start their careers in the healthcare profession under support and guidance.

Advantages of Glimepiride and Metformin Tablets

Glimepiride and Metformin tablets have various medical advantages, given below:

• Provides dual-action therapy for better blood sugar control.
• Combines insulin secretion stimulation (glimepiride) with reduced glucose production (metformin).
• Effective in lowering both fasting and post-meal blood glucose levels.
• May reduce insulin resistance over time due to metformin’s action.
• Lower risk of weight gain compared to some other antidiabetic drugs.
• Metformin may offer cardiovascular benefits in diabetic patients.
• Helps preserve pancreatic beta-cell function longer than sulfonylureas alone.
• Metformin may modestly aid in weight management.
• Glimepiride has a lower risk of severe hypoglycemia compared to older sulfonylureas.
• Metformin’s potential benefits extend beyond glycemic control.

Dosage Instructions for Glimepiride and Metformin Tablets

The directions for using Glimepiride and Metformin tablets are mentioned below:

• Take exactly as prescribed by your doctor, usually once or twice daily.
• Swallow the tablet whole with meals to reduce stomach upset.
• Do not crush, chew, or break extended-release tablets.
• Start with a low dose to minimize side effects, then adjust gradually.
• If a dose is missed, take it as soon as remembered unless close to the next dose.
• Do not double the dose to make up for a missed one.

Storage Instructions for Glimepiride and Metformin Tablets

The storage rules for Glimepiride and Metformin tablets are given below:

• Keep it at room temperature.
• Keep it in a cool and dry place.
• Protect it from sunlight.
• Keep it away from the reach of children and pets.
• Do not keep it in moisture.
• Keep it away from freezing.

Precautions for Using Glimepiride and Metformin Tablets

The safety measures for using Glimepiride and Metformin tablets are:

• Inform your doctor about any allergies before taking the tablet.
• Monitor for signs of hypoglycemia, like dizziness, sweating, or confusion
• Avoid excessive alcohol as it increases the risk of lactic acidosis.
• Inform the doctor before surgery or imaging tests requiring contrast dye.
• Not recommended for patients with severe kidney or liver disease.
• Watch for vitamin B12 deficiency with long-term metformin use.
• Report unusual muscle pain, tiredness, or breathing difficulties immediately.
• May cause gastrointestinal issues like nausea or diarrhea initially.
• Inform the doctor if pregnant, planning pregnancy, or breastfeeding.
• Caution when driving or operating machinery until the drug effects are known.
• Report any allergic reactions, like rash or swelling, promptly.

Side Effects of Having Glimepiride and Metformin Tablets 

The side effects of consuming Glimepiride and Metformin tablets are given below:

• Stomach pain
• Nausea
• Diarrhoea
• Vomiting
• Headache
• Metallic taste

Frequently Asked Questions (FAQs)

What should I do if I miss a dose?

Take it as soon as you remember, but skip if it’s close to the next dose (never double dose).

When should I seek emergency help?

If you have signs of lactic acidosis (muscle pain, trouble breathing) or severe allergic reactions.

Can I stop taking Glimepiride and Metformin tablets once my sugar is controlled?

No, always consult your doctor before stopping to avoid sugar spikes.

Do Glimepiride and Metformin tablets interact with other medicines?

Yes, inform your doctor about all medications/supplements you take.