Paracetamol, Chlorpheniramine Maleate, Phenylephrine, and Caffeine is a combination medication, composed of Paracetamol, Chlorpheniramine Maleate, Phenylephrine, and Caffeine. This combination therapy is widely prescribed to treat the Common Cold. Additionally, it is used to treat allergic symptoms, including sneezing, watery eyes, and an itchy and watery nose and throat. The Common Cold is a mild viral infection, an upper respiratory illness, that primarily affects the nose and throat, caused by Rhinoviruses. 

Paracetamol is an Analgesic and Antipyretic, which reduces fever, headaches, sore throat pain, and body aches. Chlorpheniramine Maleate belongs to the drug class known as Antihistamines. It works by offering relief from nasal irritation and allergic responses associated with cold and flu. Whereas Phenylephrine Hydrochloride is a Sympathomimetic Decongestant, relieving and improving airflow and breathing comfort. Caffeine comes under the class called Central Nervous System Stimulants, which enhances the analgesic effect of Paracetamol. 

Mestra Pharma, a leading and established name in the Pharmaceutical Landscape, offering WHO, ISO, and GMP-accredited therapeutic drugs, along with Paracetamol, Chlorpheniramine Maleate, Phenylephrine, and Caffeine tablets, marketed under the brand name COLDCARE. 

What is the Working Mechanism of Paracetamol, Chlorpheniramine Maleate, Phenylephrine, and Caffeine Tablets? 

This Tablet is a combination of analgesic and antipyretic power of Paracetamol, the anti-allergic effect of Chlorpheniramine Maleate, the decongestant action of Phenylephrine, and the mild stimulant effect of Caffeine to provide comprehensive and lasting relief. 

The Working Mechanism of this combination medication has been discussed as follows: 

Paracetamol- Being an Analgesic and Antipyretic, it works by inhibiting the cyclooxygenase COX in the brain, reducing prostaglandin synthesis, thereby lowering fever and relieving pain.

Chlorpheniramine Maleate- A First-generation Antihistamine, anti-allergic, which blocks histamine H1 receptors, hence reducing allergic symptoms such as a runny nose, sneezing, watery eyes, and itching.

Phenylephrine- It causes vasoconstriction in nasal blood vessels, reducing swelling and congestion in the nasal passages. 

Caffeine-  is a Central Nervous System Stimulant, counters drowsiness caused by antihistamines, and enhances the analgesic effect of Paracetamol. 

Uses of Paracetamol, Chlorpheniramine Maleate, Phenylephrine, and Caffeine Tablets

The Tablet is very effective in providing relief from the Common Cold symptoms and helps to treat the same, also it actively works against the allergic symptoms like sneezing, watery eyes, and much more.

The uses of this tablet have been discussed in detail as follows: 

1. Provides relief from common cold symptoms: headache, sneezing, nasal congestion, and sore throat.
2. Helps in the Management of fever and body aches.
3. Commonly used to treat sinus congestion and pressure.
4. Offers relief from allergic rhinitis, such as a runny nose, watery eyes, and itching.
5. Suitable for short-term symptomatic management. 

Possible Side Effects Caused by This Tablet

Like all medications, this combination may cause mild to moderate side effects. It will go away as the body adjusts to the treatment. Seek professional help if it persists, causing discomfort. Some of the Side Effects have been mentioned as follows: 

• Headache
• Palpitations
• Dizziness
• Restlessness
• Anxiety
• Insomnia
• Nausea
• Weakness
• Hallucination 
• Increased blood pressure

General Safety and Precautions 

While using Paracetamol, Chlorpheniramine Maleate, Phenylephrine, and Caffeine Tablets, follow these safety measures to avoid any adverse side effects. 

Some of them have been mentioned as follows:

• Consult a doctor if you have hypertension, heart disease, liver and kidney disease, diabetes, or thyroid disorders.
• Use it with caution if you are pregnant or breastfeeding. 
• Avoid exceeding the recommended dose to prevent liver or cardiovascular complications.
• Consult a doctor if your symptoms have not improved within seven days of treatment. 

How to Store Paracetamol, Chlorpheniramine Maleate, Phenylephrine, and Caffeine Tablets? 

Follow the instructions mentioned below, as follows: 

• Store below 30°C. 
• Keep it out of children’s reach. 
• Avoid direct exposure to sunlight, heat, and moisture.
• Freezing may damage the formulation.

Frequently Asked Questions (FAQ’s)

1. Can I take this if I have high blood pressure?

Phenylephrine may raise blood pressure. Consult your doctor before use.

2. What happens if I overdose?

Overdose may cause severe liver damage due to Paracetamol, irregular heartbeat, or nervous system disturbances. Seek immediate medical attention.

3. Can I take it with coffee or energy drinks?

Since it already contains caffeine, limit additional caffeine intake to avoid overstimulation.

4. How long can I take this medicine?

It is intended for short-term use only, usually 3 to 5 days. Consult your doctor if symptoms persist.