Nesufen-Plus is a combination medicine manufactured by Mestra Pharma. The medicine contains Nimesulide and paracetamol with the combined strength of 100mg and 325 mg, respectively. The active ingredients like Nimesulide and Paracetamol are the pain-relieving agents in conditions like headache, mild migraine, muscle pain, dental pain, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis or painful menses. The anti-inflammatory effects of Nimesulid with the fast-acting analgesic and antipyretic properties of Paracetamol present in the tablet. NESUFEN-PLUS ensures rapid symptom control and improves patient comfort with its balanced and clinically trusted formulation.

Mechanism of Action  

The working of Nesufen-plus is based on the following principles:

• Nimesulide acts by inhibiting inflammatory mediators (prostaglandins), thereby reducing pain, swelling, and redness in the affected area.
• Paracetamol works mainly in the central nervous system to lower fever and provide quick relief from pain.

Indications for its Use

Here are some of the conditions when a patient should consume the Nesufen-plus tablets 

• Headache & migraine
• Dental pain
• Musculoskeletal pain
• Joint pain & arthritis
• Fever
• Post-operative pain
• Ear, throat, and sinus pain
• Pain due to injury or sprain

Dosages and Instructions

The tablet is a highly effective formulation, so it must only be used as per the prescription by a healthcare specialist. The general prescription of the tablet shows

• For adults, the tablet must be taken twice a daily after consuming meal. 
• Must take the tablets as prescribed, do not exceed or miss the dosages. 
• Do not chew, crush or break the tablets; swallow the tablets as a whole. 

Possible Side Effects 

Generally, the medicine has a high tolerance, but sometimes it may show certain side effects. Visit your doctor if the symptoms appear for a long these side effects can be 

• Nausea or vomiting
• Gastric discomfort
• Dizziness or headache
• Skin rash (rare)
• Mild acidity

Precautions 

While using the Nesufen-Plus tablet, there are certain precautions must be considered while consuming the tablets any unwanted conditions.

• Avoid in patients with liver disorders, gastric ulcers, or kidney impairment.
• Not recommended during pregnancy or breastfeeding unless advised by a doctor.
• Avoid alcohol consumption while on this medication.
• Do not use in children without medical supervision.
• Individuals allergic to NSAIDs should avoid this product.

Storage Instructions 

• Store it in a cool and dry place
• Keep it away from children. 
• Keep away from sunlight and moisture.